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DTSTAMP:20260605T154540Z
LOCATION:Bldg. 6 - Room 103
DTSTART;TZID=Europe/Stockholm:20260629T143000
DTEND;TZID=Europe/Stockholm:20260629T150000
UID:submissions.pasc-conference.org_PASC26_sess108_msa266@linklings.com
SUMMARY:Particle Tracing and Thrombus Adhesion on Fluttering Bioprosthetic
  Aortic Valve Leaflets
DESCRIPTION:Nataliya Sevryugina and Dominik Obrist (ARTORG Center for Biom
 edical Engineering Research)\n\nSubclinical Bioprosthetic Valve Thrombosis
  (BPVT) has a reported incidence of 3% to 45%; the underlying thrombus adh
 esion processes could be related to leaflet fluttering. To investigate thi
 s, wall shear stress (WSS) patterns are analysed in fluttering and non-flu
 ttering bioprosthetic aortic valve (BHV) models.  \n\nThose BHV models wer
 e simulated with a high-fidelity fluid-structure interaction solver. To as
 ses BPVT, Massless Lagrangian particles were released at systole onset and
  traced with BDI computation, while WSS map on aortic leaflet's side asses
 sed potential adhesion.\n\nFor a single 1025 particles release, the flutte
 ring valve (40Hz leaflet fluttering), showed on average 3.7x higher BDI fo
 r advected particles. This high fluttering-related BDI risk may be mitigat
 ed as fluttering motion generates high amplitude WSS that can promote the 
 recirculation and prevent thrombus deposition on the leaflet.\n\nWhile non
 -fluttering valve (<0.5mm amplitude,  >200Hz vibrations of the leaflet tip
 s) have lower BDI risk, it presents  low amplitude WSS pattern. Suggesting
  the existence of small-scale vortical structures that can trap the thromb
 i at the end of the systole.\n \nThese findings identify fluttering as a c
 ontradictory phenomenon: it favours BPVT by increasing BDI, while potentia
 lly reducing  thrombus deposition by increasing WSS on the leaflets. Furth
 er research is required to resolve this contradiction.\n\nDomain: Engineer
 ing, Life Sciences, Computational Methods and Applied Mathematics\n\nSessi
 on Chair: Dominik Obrist (University of Bern)\n\n
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