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DTSTAMP:20260605T154541Z
LOCATION:Bldg. 8 - Room B 101
DTSTART;TZID=Europe/Stockholm:20260629T150000
DTEND;TZID=Europe/Stockholm:20260629T153000
UID:submissions.pasc-conference.org_PASC26_sess110_msa263@linklings.com
SUMMARY:A Hospital-Integrated Digital Twin Ecosystem for Translational Mus
 culoskeletal AI
DESCRIPTION:John Garcia-Henao (Balgrist University Hospital)\n\nArtificial
  intelligence is rapidly transforming musculoskeletal (MSK) medicine throu
 gh advances in multimodal imaging, segmentation foundation models, and cli
 nical data integration. However, translating these systems from research i
 nto clinical practice remains limited by fragmented infrastructures, restr
 icted data access, and insufficiently reproducible evaluation workflows.\n
 We present a hospital-integrated digital twins ecosystem designed to suppo
 rt trustworthy and scalable translational MSK AI research. The platform co
 mbines two complementary systems: MIRO (Medical Image Research Orchestrati
 on) and DORIS (Distributed Orchestration of Research Imaging Subsets). MIR
 O enables governed PACS connectivity, de-identification, interactive 3D an
 notation, and clinically integrated AI benchmarking within a Trusted Resea
 rch Environment. DORIS closes the reproducibility loop through a four-laye
 r FAIR catalog, snapshot-frozen dataset identities, license-aware publicat
 ion workflows, and cross-tier validation mechanisms that guarantee bit-ide
 ntical segmentation verdicts between hospital Trusted Research Environment
 s and public Hugging Face mirrors. Together, MIRO and DORIS demonstrate ho
 w HPC-enabled, federated, and license-aware digital twin infrastructure ca
 n transform hospital MSK cohorts into auditable virtual patients, supporti
 ng reproducible multimodal AI research and future AI-driven in-silico clin
 ical trials for translational medicine.\n\nDomain: Engineering, Life Scien
 ces, Computational Methods and Applied Mathematics\n\nSession Chairs: John
  Anderson Garcia Henao (University of Bern, ARTORG Center for Biomedical E
 ngineering Research) and Carlos Barrios Hernandez (Universidad Industrial 
 de Santander, LIG/INRIA - CITI Laboratory)\n\n
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