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DTSTAMP:20260421T090512Z
LOCATION:Bldg. 6 - Room 102
DTSTART;TZID=Europe/Stockholm:20260629T160000
DTEND;TZID=Europe/Stockholm:20260629T164000
UID:submissions.pasc-conference.org_PASC26_sess119_msa220@linklings.com
SUMMARY:Breaking the disciplinary silos: federated, FAIR, and fair approac
 hes for Virtual Human Twins in health and care
DESCRIPTION:Liesbet Geris (KU Leuven, VPH society)\n\nFollowing the Europe
 an Commission (EC) definition, a Virtual Human Twin (VHT) is a digital rep
 resentation of human health or disease across multiple anatomical scales, 
 from cells to organ systems. Built from computational models and heterogen
 eous data, VHTs aim to simulate and predict physiological behavior, includ
 ing interactions with comorbidities. Their potential lies in enabling targ
 eted prevention, personalized clinical pathways, and advanced decision sup
 port, with applications such as in silico clinical trials, medical trainin
 g, and surgical planning. A key enabler is a federated public infrastructu
 re (Advanced Simulation Platform, currently under construction through an 
 EC procurement) that integrates distributed resources, including data, mod
 els, algorithms, and high-performance computing capabilities, while suppor
 ting model validation and credibility assessment. Such an infrastructure r
 equires interoperability, scalable workflows, and adherence to FAIR and eq
 uitable data principles.\nAn ecosystem-driven roadmap has been developed (
 https://zenodo.org/records/14769224) to define the technical, ethical, leg
 al, and social requirements for VHT deployment. It describes the needs and
  trends in the ecosystem, addresses technological aspects, such as interop
 erability, computability, and data integration, as well as non-technologic
 al aspects including privacy, intellectual property and societal acceptanc
 e, alongside sustainability and stakeholder engagement. This presentation 
 highlights current progress, challenges, and future directions towards a f
 ederated VHT infrastructure for health and care.\n\nDomain: Climate, Weath
 er, and Earth Sciences, Engineering, Life Sciences, Computational Methods 
 and Applied Mathematics\n\nSession Chairs: Maria Grazia Giuffreda (ETH Zur
 ich / CSCS), Florina Ciorba (University of Basel), Marie-Christine Sawley 
 (ICES Foundation), and Maria Girone (CERN)\n\n
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