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DTSTART:19700308T020000
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BEGIN:VEVENT
DTSTAMP:20260421T090513Z
LOCATION:Bldg. 6 - Room 004
DTSTART;TZID=Europe/Stockholm:20260701T150000
DTEND;TZID=Europe/Stockholm:20260701T153000
UID:submissions.pasc-conference.org_PASC26_sess160_msa136@linklings.com
SUMMARY:Computational and Experimental Investigation of Avidin–DNA Interac
 tions for the Rational Design of DNA Delivery Platforms[
DESCRIPTION:Simone Bernardotto and Margherita Morpurgo (University of Pado
 va) and Miroslava Nedyalkova and Marco Lattuada (University of Fribourg)\n
 \nGene delivery requires molecular systems capable of binding, protecting,
  and transporting nucleic acids. Avidin, a tetrameric glycoprotein best kn
 own for its strong affinity for biotin, has recently attracted attention f
 or its ability to interact with nucleic acids and form stable nanoassembli
 es. Such interactions have been exploited in the development of multifunct
 ional diagnostic and therapeutic systems, including avidin-based nanostruc
 tures designed for nucleic acid delivery. However, despite the growing int
 erest in these systems, the molecular determinants governing avidin–DNA bi
 nding remain only partially understood.\nProtein–DNA interactions were inv
 estigated computationally allowing identification of the most plausible bi
 nding orientations and interaction interfaces between avidin and DNA. Anal
 ysis of the docking results indicates that avidin–DNA association is prima
 rily driven by electrostatic interactions between positively charged regio
 ns on the avidin surface and the negatively charged phosphate backbone of 
 DNA. Additional contributions from nucleobase–protein contacts may further
  stabilize the complex depending on the sequence and structural context of
  the nucleic acid.\nThese findings provide structural insight into avidin–
 DNA interactions and contribute to the rational design of avidin-based pla
 tforms for nucleic acid delivery and gene therapy applications.\n\nDomain:
  Chemistry and Materials\n\nSession Chair: Miroslava Nedyalkova (Universit
 y of Fribourg)\n\n
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